Alltera Tablet (Lopinavir 200mg and Ritonavir 50mg) – Overview

Alltera Tablet contains Lopinavir 200 mg and Ritonavir 50 mg is a fixed-dose antiretroviral combination used in the management of HIV-1 infection. It contains two protease inhibitors: lopinavir (the primary active agent) and ritonavir (mainly as a pharmacokinetic enhancer).

Medical Uses / Indications

Indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children aged 14 days or older.

How Alltera Tablet Works (Mechanism of Action)

Both drugs inhibit the HIV-1 protease enzyme, which is essential for viral replication and maturation. Ritonavir’s main role at this dose is to inhibit the metabolism of lopinavir, increasing its blood levels and effectiveness.

Dosage & Administration

• The typical adult dose is 400 mg lopinavir/100 mg ritonavir (two tablets) taken twice daily with food.
• Pediatric dosing varies by weight and age; consult a healthcare provider.
• Tablets should be swallowed whole and not chewed, broken, or crushed.

Possible Side Effects

• Common: Diarrhea, nausea, vomiting, abdominal pain, headache, and elevated cholesterol or triglycerides.
• Serious: Pancreatitis, liver problems, heart rhythm changes (QT/PR prolongation), severe allergic reactions, and changes in fat distribution.

Drug Interactions

• Ritonavir is a potent inhibitor of liver enzymes (CYP3A4) and can increase or decrease the levels of many medications.
• Interacts with drugs such as antiarrhythmics, sedatives, anticoagulants, statins, and others.
• Always inform your healthcare provider of all medications and supplements you are taking.

Precautions

• Use caution in patients with liver disease, heart problems, or pancreatitis.
• Monitor blood glucose and lipid levels during therapy.
• Use effective contraception if of childbearing potential (may reduce effectiveness of hormonal contraceptives).

Storage & Handling

• Store tablets at room temperature (20°C to 25°C/68°F to 77°F).
• Keep in original container, tightly closed, and away from moisture and heat.

Missed Dose

• If a dose is missed, take it as soon as possible with food.
• If it is almost time for the next dose, skip the missed dose and continue with your regular schedule.
• Do not take two doses at once.

Always consult your healthcare provider or pharmacist for personalized medical advice and before making any changes to your medication regimen.