Duovir-N Tablet (Lamivudine 150mg, Zidovudine 300mg and Nevirapine 200mg) – Overview

Duovir-N Tablet contains Lamivudine 150mg, Zidovudine 300mg and Nevirapine 200mg is a fixed-dose combination antiretroviral medication used in the management of HIV infection. This combination helps reduce the amount of HIV in the body, improving immune function and decreasing the risk of developing AIDS-related complications.

Medical Uses / Indications

This medication is indicated for the treatment of HIV-1 infection in adults and adolescents as part of antiretroviral therapy (ART). It is prescribed in combination with other antiretroviral agents.

How Duovir-N Tablet Works (Mechanism of Action)

• Lamivudine and Zidovudine are nucleoside reverse transcriptase inhibitors (NRTIs) that block reverse transcriptase, an enzyme HIV needs to replicate.
• Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds directly to reverse transcriptase, inhibiting viral replication.

Together, these medicines suppress HIV replication and reduce viral load.

Dosage & Administration

• The usual adult dose is one tablet taken orally twice daily, or as directed by your healthcare provider.
• Take with or without food.
• Do not crush or split the tablets.

Possible Side Effects

• Common: Nausea, headache, fatigue, diarrhea, rash, cough.
• Serious: Severe skin rash (Stevens-Johnson syndrome), liver toxicity, lactic acidosis, pancreatitis, anemia, neutropenia, hypersensitivity reactions. Seek immediate medical attention if you experience signs of severe allergic reactions, jaundice, or unusual fatigue.

Drug Interactions

• May interact with other antiretroviral drugs, antifungals, anticonvulsants, and certain antibiotics.
• Tell your doctor about all medications and supplements you are taking.

Precautions

• Inform your doctor of any history of liver disease, kidney problems, or bone marrow suppression.
• Regular blood tests may be required to monitor for toxicity.
• Not recommended during pregnancy unless prescribed.
• Use effective contraception during treatment.

Storage & Handling

• Store at room temperature (20–25°C), away from moisture and heat.
• Keep out of reach of children

Missed Dose

• Take the missed dose as soon as you remember.
• If it is almost time for your next dose, skip the missed dose and continue your regular schedule.
• Do not take two doses at once.