Kocitaf Tablet (Dolutegravir 50mg, Emtricitabine 200mg and Tenofovir Alafenamide 25mg) – Overview

Kocitaf Tablet contains Dolutegravir 50mg, Emtricitabine 200mg, and Tenofovir Alafenamide 25mg. Kocitaf tablet is an antiretroviral medications used in combination to treat HIV-1 infection in adults and children. This fixed-dose combination provides a convenient and effective option for managing HIV by lowering viral load and improving overall immune function.

Medical Uses / Indications

This combination therapy is indicated for:

• Treatment of HIV-1 infection in adults and pediatric patients.
• Patients with HIV who have not received prior antiretroviral therapy.
• Patients switching from a stable antiretroviral regimen due to virological concerns.

How Kocitaf Tablet Works (Mechanism of Action)

• Dolutegravir 50mg is an integrase strand transfer inhibitor (INSTI) that blocks the integration of viral DNA into the host’s genome.
• Emtricitabine 200mg is a nucleoside reverse transcriptase inhibitor (NRTI) that prevents the reverse transcription of viral RNA into DNA.
• Tenofovir Alafenamide 25mg is also a nucleotide reverse transcriptase inhibitor (NRTI) that works more effectively with a lower dose and reduced side effects compared to its predecessor Tenofovir Disoproxil Fumarate.

Dosage & Administration

The recommended dosage for adults and children over 12 years is one tablet containing Dolutegravir 50mg, Emtricitabine 200mg, and Tenofovir Alafenamide 25mg taken orally once daily, with or without food. For children under 12 or for specific dosing adjustments, consult a healthcare professional.

Possible Side Effects

Common side effects may include:

• Diarrhea
• Nausea
• Fatigue
• Headache
• Insomnia

Serious side effects may include:

• Liver problems (indicated by jaundice)
• Severe allergic reactions
• Lactic acidosis
• Renal impairment

Patients should seek medical attention immediately if they experience symptoms like swelling, rash, or difficulty breathing.

Drug Interactions

Dolutegravir, Emtricitabine, and Tenofovir Alafenamide may interact with other medications. Inform your healthcare provider of all medications, supplements, and herbal products being taken. Notable interactions may include:

• Certain antacids and supplements containing calcium or iron
• John’s Wort
• Some antibiotics and antifungal medications

Precautions

• Regular monitoring of kidney function is advisable for those taking this medication.
• Tested for Hepatitis B virus (HBV) prior to initiation of therapy.
• Use caution in patients with a history of liver disease or those receiving other medications affecting the liver.
• Discuss with a healthcare provider before stopping or changing any part of the treatment regimen.

Storage & Handling

Store at room temperature, away from moisture and heat. Ensure that the medication is kept out of reach of children. Do not use the medication beyond the expiration date printed on the package.

Missed Dose

If a dose is missed, take it as soon as you remember. If it is close to the time of the next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to compensate for a missed dose.

For any further questions or concerns regarding Kocitaf Tablet, consult with a healthcare professional.