Tudobest LE Tablet (Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg + Efavirenz 600mg) – Overview

Tudobest LE Tablet Contains Lamivudine (300mg), Tenofovir disoproxil fumarate (300mg), and Efavirenz (600mg) are components of a combination antiretroviral therapy (cART) used to treat HIV-1 infection in adults and children over a certain age. This combination works synergistically to suppress viral replication and improve immune function in individuals with HIV.

Medical Uses / Indications

This medication is indicated for the treatment of HIV-1 infection and is typically used in combination with other antiretroviral agents. It is not a cure for HIV but helps manage the virus and reduce the likelihood of transmission.

How Tudobest LE tablet Works (Mechanism of Action)

Lamivudine: A nucleoside reverse transcriptase inhibitor (NRTI) that is incorporated into the viral DNA, preventing the reverse transcription process and halting viral replication.

Tenofovir Disoproxil Fumarate: Also an NRTI that inhibits reverse transcriptase, leading to the termination of the viral DNA chain during replication.

Efavirenz: A non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds directly to reverse transcriptase, altering its shape and function, which prevents the replication of the virus.

Dosage & Administration

The recommended dosage is one tablet taken orally once daily, ideally at the same time each day. It can be taken with or without food, although taking it with food may help minimize gastrointestinal side effects. Prescribing physicians should adjust the dosage based on individual patient profiles and other factors.

Possible Side Effects

Common side effects include:

• Fatigue
• Nausea
• Headache
• Diarrhea
• Insomnia

Serious side effects may include:

• Liver issues or hepatitis B flare-ups
• Lactic acidosis
• Severe allergic reactions
• Mental health changes, such as depression or suicidal thoughts

Patients are advised to discuss any concerning symptoms with their healthcare provider promptly.

Drug Interactions

Tudobest LE tablet may interact with other drugs, especially those that influence liver enzymes such as cytochrome P450. Patients should inform their healthcare provider of all medications, supplements, and over-the-counter drugs they are taking to avoid potential interactions.

Precautions

Patients should be screened for HIV drug resistance prior to initiation of therapy. Regular monitoring of liver function and renal function is required due to potential risks. Pregnant women or those planning to become pregnant should discuss the risks and benefits with their healthcare provider.

Storage & Handling

Store at room temperature, away from moisture and heat. Keep out of reach of children. Do not use if the expiration date has passed.

Missed Dose

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double up to make up for a missed dose.