Duovir Tablet (Zidovudine 300mg and Lamivudine 150mg) – Overview

Duovir Tablet Contains Zidovudine 300mg and Lamivudine 150mg is a combination antiviral medication used primarily in the treatment of HIV (Human Immunodeficiency Virus) infection. It works by inhibiting the replication of HIV in the body, helping to manage the disease and improve immune function.

Medical Uses / Indications

This medication is indicated for the treatment of HIV-1 infection in adults and pediatric patients. It is typically used as part of a comprehensive antiretroviral therapy regimen to reduce viral load, improve CD4 cell counts, and lower the risk of HIV transmission.

How Duovir tablet Works (Mechanism of Action)

Zidovudine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the reverse transcription process of HIV, preventing the virus from converting its RNA into DNA. Lamivudine, another NRTI, inhibits the replication of HIV by preventing viral DNA synthesis. Together, they provide a synergistic effect in suppressing viral replication.

Dosage & Administration

The recommended dosage for adults is one tablet of Zidovudine 300mg + Lamivudine 150mg taken orally, typically once or twice a day, or as directed by a healthcare professional. Dosage may vary based on individual health conditions and treatment response.

Possible Side Effects

Common side effects may include:

• Nausea
• Fatigue
• Headache
• Dizziness

Serious side effects may include:

• Anemia
• Neutropenia (low white blood cell count)
• Lactic acidosis
• Hepatotoxicity

Patients should report any unusual or severe reactions to their healthcare provider.

Drug Interactions

Zidovudine and Lamivudine may interact with other medications, including but not limited to:

• Other antiretroviral drugs
• Certain antibiotics
• Medications that affect liver enzymes (such as rifampin)

It is essential to inform your healthcare provider of all medications being taken to avoid potential interactions.

Precautions

Before starting this medication, patients should inform their healthcare provider of any history of liver disease, bone marrow suppression, or pancreatitis. Regular monitoring of blood counts and liver function is advised during treatment.

Storage & Handling

Store Zidovudine 300mg + Lamivudine 150mg at room temperature, away from moisture and heat. Keep out of reach of children and do not use after the expiration date.

Missed Dose

If a dose is missed, it should be taken as soon as remembered. If it is almost time for the next dose, skip the missed dose and return to the regular dosing schedule. Do not take two doses at once to make up for a missed dose.

For further information and personalized advice, consult your healthcare provider.