Acriptega Tablet (Dolutegravir 50mg, Lamivudine 300mg, and Tenofovir disoproxil fumarate 300mg) – Overview

Acriptega Tablet contains Dolutegravir 50mg, Lamivudine 300mg, and Tenofovir disoproxil fumarate 300mg. Acriptega tablet is a combination antiviral medication used for the treatment of HIV-1 infection in adults and children over the age of 12 years. This fixed-dose combination helps to suppress viral replication, allowing the immune system to better combat the infection.

Medical Uses / Indications

This medication is indicated for the treatment of HIV-1 in conjunction with other antiretroviral therapies. It is part of a comprehensive treatment plan aimed at achieving and maintaining viral suppression.

How Acriptega Tablet Works (Mechanism of Action)

• Dolutegravir is an integrase strand transfer inhibitor (INSTI) that blocks the integration of viral DNA into the host cell genome, preventing the virus from replicating.
• Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the virus’s ability to replicate its genetic material.
• Tenofovir disoproxil fumarate is another NRTI that acts by inhibiting the reverse transcriptase enzyme, leading to the termination of the viral DNA chain. Together, these components work synergistically to suppress HIV viral load.

Dosage & Administration

The recommended dosage for adults and children over 12 years is one tablet daily, taken orally, with or without food. Adherence to the prescribed dosing schedule is crucial for the effectiveness of the therapy.

Possible Side Effects

Common side effects can include nausea, diarrhea, fatigue, headache, and insomnia. Serious side effects may include liver problems, allergic reactions, lactic acidosis, and changes in kidney function. It is essential to inform your healthcare provider of any unusual symptoms or severe reactions.

Drug Interactions

Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg may interact with various medications, including certain antacids, antiepileptics, and other drugs that affect liver enzymes. Always discuss your medication list with your healthcare provider to avoid potential interactions.

Precautions

Patients should be assessed for prior hypersensitivity reactions to any components of the medication. It is important to monitor kidney function regularly during treatment, as well as to evaluate liver health for any changes. Discuss any plans for pregnancy or current pregnancy with your healthcare provider.

Storage & Handling

Store the medication in a cool, dry place away from direct light and moisture. Keep out of reach of children and do not use after the expiration date printed on the packaging.

Missed Dose

If you miss a dose of Acriptega tablet, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. Always consult your healthcare provider for further guidance if you miss a dose.