Twinaqt Tablet (Dolutegravir 50mg and Lamivudine 300mg) – Overview

Twinaqt Tablet contains Dolutegravir 50mg and Lamivudine 300mg. It is a combination medication used in the management of Human Immunodeficiency Virus (HIV) infection. It targets the virus at different stages of its lifecycle, thus helping to suppress viral replication and improving overall immune function.

Medical Uses / Indications

This combination therapy is indicated for the treatment of HIV-1 infection in adults and children. It is often utilized as a part of a comprehensive antiretroviral therapy regimen to achieve viral load suppression.

How Twinqt Tablet Works (Mechanism of Action)

Dolutegravir is an integrase strand transfer inhibitor (INSTI) that works by blocking the integrase enzyme, preventing the integration of viral DNA into the host cell’s genome. Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the reverse transcriptase enzyme, thereby inhibiting viral replication. Together, they provide a robust response against HIV by targeting multiple pathways involved in the virus’s lifecycle.

Dosage & Administration

The usual recommended dosage for adults and children aged 12 years and older is one tablet containing 50mg of Dolutegravir and 300mg of Lamivudine, taken once daily, with or without food. Always follow healthcare provider instructions regarding specific dosing based on individual health needs.

Possible Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Fatigue
• Insomnia

Serious side effects may include:

• Liver problems (indicated by jaundice or dark urine)
• Allergic reactions (skin rash, itching, swelling)
• Severe gastrointestinal issues

Seek immediate medical attention if you experience any signs of a serious allergic reaction or other severe side effects.

Drug Interactions

Dolutegravir and Lamivudine may interact with other medications, leading to either increased side effects or reduced efficacy. It is crucial to inform your healthcare provider about all medications, supplements, and herbal products you are currently taking.

Precautions

Before starting this medication, inform your healthcare provider if you have any prior history of liver disease, kidney issues, or other significant health conditions. Regular monitoring of liver function and overall health parameters during treatment is recommended.

Storage & Handling

Store Twinaqt tablet at room temperature, away from direct light and moisture. Keep it out of the reach of children and pets. Do not use the medication beyond its expiration date.

Missed Dose

If you miss a dose of Twinaqt tablet, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed dose and continue with your regular schedule. Never double the dose to catch up.

For more detailed information, consult your healthcare provider or pharmacist.